Abstract
Summary
1. Intravenous infusion of sorbitol in rabbits causes a prompt fructosemia which subsides relatively rapidly following cessation of infusion. A more variable secondary glucosemia occurs following the rise in blood fructose and during the subsidence of the fructosemia. These findings in the intact animal are in accord with previous observations by others on sorbitol metabolism by rat liver slices and homogenates. 2. Although rapidly metabolized, a small amount of sorbitol appears in the urine with infusion rates as low as .33 g/kg/hr.
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