Lathyrus Factor Activity of Beta-Aminopropionitrile and Related Compounds. ∗

Abstract

Summary

β-amino propionitrile will produce all the changes which have been described in rats fed 50% Lathyrus odoratus pea meal. None of the supplements fed with BAPN inhibited the development of skeletal deformities. Substitution of a methyl or acetyl into the amino group or a substitution of hydroxy for the amino group in BAPN results in a loss of biologic activity. Unlike BAPN which principally modifies bone development and produces marked skeletal deformity, Bis-β-(cyanoethyl)-amine exerts an early and pronounced influence on the central nervous system and subsequently produces lesser skeletal alterations.