Clot Density Determination of Fibrinogen in Experimental Myocardial Infarction

Abstract

Summary

1. In vitro experiments indicate that the clot density determination of fibrinogen may be applicable to either human as well as canine plasma. 2. Fifty dogs were subjected to a) sham-operation, b) high coronary artery ligation, c) low coronary artery ligation. 3. Significant differences in the mean fibrinogen levels were found in the three groups corresponding to the various degrees of myocardial necrosis. 4. These results seem to bear out a previously reached clinical impression that the maximum fibrinogen concentration parallels the extent of the myocardial infarct.