Abstract
Summary
1. Canine plasma and serum possess potent antiaccelerator activity, probably anticonvertin. This activity is retained after dialysis, but is thermolabile and is inactivated by multiple ether extractions. It is found in the precipitate obtained between 50 and 80% saturation with ammonium sulfate. Separation from antithrombin has not been accomplished. 2. An assay procedure for determining relative antiaccelerator activity is described. 3. Normal and hemophilic plasma and normal serum all have approximately the same antiaccelerator activity. 4. It is suggested that this new activity limits the tide of SA during clotting, analogous to antithrombin and the thrombin tide.
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