Abstract
Summary and Conclusions
1. Experiments were made to determine the effect of a new compound, nicotinhydroxamic acid methio-dide (NHMI), on isolated mammalian tissue treated with TEPP. 2. NHMI possesses the property of reversing to a significant degree the TEPP-induced actions in isolated auricles and intestinal strips of the rabbit. 3. That this effect of NHMI was not the result of an anticholinergic action was shown by the inability of the compound to reverse the effects of ACh or MCh. 4. That this reversal phenomenon was not the result of a direct action upon the tissue was shown by the negligible response of the organs to the compound alone. 5. These studies indicate that reversal of TEPP-in-duced effects by NHMI may be due to a true chemical reactivation of cholinesterase.
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