Abstract
Summary
1. The original intention of this investigation was to determine whether FSH would restore estrogen damaged testes of rats to normal. 2. Restoration of normal testicular activity did not occur. Instead fibrotic degeneration of tubules and periarteritis of interstitial arterioles eventually developed. 3. In animals autopsied 8 to 12 months after treatment periarteritis nodosa was present in intestinal mesenteric, pancreatic, splenic, and other small arteries, but not in pulmonary arterioles. Small vessels of kidneys, adrenals, and pituitary were also involved. 4. Lymph-oidal hyperplasia was an accompanying reaction. 5. Eventual testicular degeneration-atrophy, hyperplastic and tumorlike proliferations of the pituitary and adrenal glands seem to result in a delayed and prolonged production of periarteritis very possibly due to a DCA-like adrenal hormone.
Get full access to this article
View all access options for this article.