Abstract
Summary
Fresh preparations of the WS strain of influenza A virus were poorly absorbed by Ehrlich tumor cells but heated WS virus formed a loose union dissociable by treatment with RDE. The neurotropic variant of this virus (NWS), which is capable of multiplying in transplanted Ehrlich ascites tumor, readily combined with EAC cells and did not elute spontaneously. RDE and sodium periodate destroyed the tumor cell receptors of NWTS virus. However, NVVS virus hemagglutinin could not be liberated by RDE after interaction with intact EAC cells at 37°C for 105 minutes. This “fixation” of NWS virus was not demonstrable after shorter periods of incubation, at temperatures of 23°C and 1°C, or if the tumor cells were previously heated to 56°C.
Get full access to this article
View all access options for this article.