Abstract
Summary
(1) Bile acids have been found to influence, in vitro, the activity of rat liver glucose-6-phosphatase, concentrations of 5 × 10-4 M inactivating and 1 × 10-3 M activating the enzyme. (2) Glucose-6-phosphatase from both normal and diabetic rats responds similarly. The increased glucose-6-phospha-tase activity found in liver of alloxan diabetic rats therefore does not appear to be due to any such activation mechanism, but rather due to an actual increase in the amount of enzyme present.
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