Phospholipide Metabolism in Various Tissues of Cholesterol-Fed Rabbits. ∗

Abstract

Summary

Rabbits maintained for 5 months on an atherogenic diet showed a marked increase in the incorporation of radioactive phosphate into the phospholipides of aorta, plasma, and the whole liver. In contrast the feeding of cholesterol and fat did not appear to have an appreciable effect on phospholipide synthesis in lung, small intestine, kidney, and muscle. The livers of the cholesterol-fed animals showed a marked increase in tissue mass over and above that caused by fatty infiltration; other organs except aorta did not exhibit significant changes in weight. A possible relationship between fatty infiltration and phospholipide turnover is discussed.