Abstract
Summary
Earlier investigations on liver nucleoprotein changes following hypophysectomy have been extended showing that the DNA per average nucleus is increased. This is not restored to normal values rapidly, since treatment for one week with growth hormone effects no appreciable reduction. These data obtained by chemical analyses strongly indicated that following hypophysectomy there was an increase in the frequency of nuclei of higher ploidy. This was found to be the case when the nuclei were examined by microspectropho tome trie technics. The results suggest that growth hormone may be important in effecting the conversion of diploid to the tetraploid nuclei. However, tetraploid nuclei may be converted to octaploid nuclei in the absence of growth hormone.
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