Abstract
Summary
1. Feeding of 0.1% sulfaquin-oxaline in the presence of 3-5% alfalfa and 5 nig of menadione per lb. of feed resulted in occurrence of a hemorrhagic syndrome in chicks. Hemorrhages closely resembled those encountered in field cases of hemorrhagic disease and, in many cases were accompanied by reduced hematocrits. In some groups blood clotting time was increased by feeding sulfa-quinoxaline. A higher incidence of hemorrhages was observed in chicks fed sulfa-quinoxaline in broiler rations than in chicks fed starter rations containing this drug. Feeding of iodinated casein as a stress factor increased the toxic effect of sulfaquinoxaline. The toxic effect of sulfaquinoxaline was slight in chicks fed the drug starting at day-old or at 2 weeks of age but was more pronounced in chicks fed the drug at 3, 4 or 5 weeks of age. Dietary penicillin appeared to increase the toxicity of sulfaquinoxaline. 2. The adverse effects of sulfaquinoxaline in these experiments are not to be interpreted to mean that sulfaquinoxaline and similar substances cannot be used as satisfactory coccidiostats under certain conditions.
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