Abstract
Summary
Offspring of vit. B12 deficient rats usually died within a period of 2 to 3 days, but before death they had a high blood urea and low liver glycogen. At an age of about 1 day, the deoxypentose nucleic acid concentration per gram of brain tissue was higher than normal and this was associated with an increased number of nuclei so that the DNA concentration per nucleus was unchanged. The pentose nucleic acid concentration per cell was lower in brain tissue from deficient offspring, but there was little change in liver tissue.
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