Abstract
Summary
Urinary uric acid output of 2 healthy male subjects on an hourly feeding regimen was markedly increased on the first day of probenecid ingestion. The amount of uric acid excreted the second day of probenecid administration was greater than normal but not as great as on the first day. This is in contrast to the previous finding that patients with normal amounts of body urate do not show a long term uricosuria after probenecid or phenylbutazone. It is suggested that these drugs induce uricosuria in all cases but that this uricosuria is self-limiting in subjects with no body stores of urate since equilibrium between urate production and disposal must be re-established.
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