Abstract
Summary
1. EDTA stimulates the accumulation of OAA during succinate oxidation. Although apparently DPN is required for this action, the results indicate that other systems concerned with the utilization of OAA are also involved in the EDTA effect. 2. Mg++, Mn++, or Ca++ prevent the effect of EDTA in increasing accumulation; the former 2 ions by activating a system concerned with utilization, the latter ion by inhibiting the formation of OAA. 3. Succinate oxidation is inhibited by EDTA only when the latter simultaneously stimulates OAA accumulation. 4. Mg++ increases OAA accumulation produced by DPN but in the presence of this ion the keto acid shows a diminished capacity to inhibit succinate oxidation.
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