Effect of 2-Acetylamino-1,3,4-Thiadiazole-5-Sulfonamide (Diamox) on Sodium,Potassium,Bicarbonate and Buffer Content of Saliva. ∗

Abstract

Summary and Conclusions

1. Daily administration of 2-acetylamino-l, 3, 4-thiadiazole-5-sulfonamide provokes a pronounced decrease in sodium, bicarbonate and buffer content of paraffin-stimulated human saliva in both normotensive and hypertensive patients. Potassium level of saliva was not affected. 2. Changes in saliva sodium, potassium, bicarbonate and buffer content which followed administration of carbonic anhydrase inhibitor were similar to those observed in normotensive persons in whom metabolic acidosis was induced with ammonium chloride.