Enzyme Studies in Muscular Dystrophy. I. Muscle Proteolytic Activity and Vitamin E-Deficiency. ∗

Abstract

Summary

1. The proteolytic activity of homogenates and extracts of muscles of rabbits with muscular dystrophy induced by vit. E-deficiency was assayed with denatured hemoglobin as substrate. 2. Vit. E-deficiency resulted in increased proteolytic activity per g wet weight of muscle and per mg of muscle protein nitrogen of both the extracts and homogenates. 3. No change in proteolytic activity of spleen, kidney or liver was observed during vit. E-deficiency.