Abstract
Summary
One hundred fifty rats of the Wistar inbred strain bearing #8 lymphomas which had grown for 8 to 16 days following transplantation and had attained sizes ranging from approximately 26 × 22 × 20 mm to 50 × 40 × 22 mm, were fed pulverized Purina chow containing 0.3% of 4−(p-dimethyl-aminostyryl) quinoline methiodide; and 90 rats bearing #8 lymphomas which had grown for about the same number of days and had reached about the same size, received chow containing 0.3% of 4−(p-dimethylamino-styryl) quinoline methochloride. Complete regression of the original lymphoma occurrec in all the rats during 10 to 18 days treatmem with the styryl quinoline compounds. Then was no recurrence of tumor at the original site during a 60-day observation period following the initial treatment. In the lattei 30 days of observation 23 of the 240 treatec rats died. In this period approximately 50% of the surviving rats developed metastatic axillary or inguinal growths. All of these metastases regressed completely after a second oral administration of the respective styryl quinoline (again as a 0.3% concentration in powdered chow) for 10 days. One hundred twenty control rats implanted subcutaneously with lymphoma #8 at the same time as the treated rats died in 18 to 21 days. The average weight of the lymphomas excised from the control rats after death was 61 g.
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