Abstract
Summary
The 9 alpha-halo derivatives of adrenal steroids are highly potent compounds and are capable of maintaining the adrenal-ectomized dog free from all signs and symptoms of insufficiency at very low doses. Fluorocorticosterone was the most active compound tested and proved to be equal in potency to aldosterone. Fluoro-F-acetate was 4.5-9 times more active and chloro-F-acetate more than twice as potent as DOC. Daily doses of the fluoro-F-compound, given orally in large doses, induced marked polydipsia and polyuria accompanied by oedema of the hind legs and scrotum.
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