Abstract
Conclusions
1. Levallorphan when given to mice produces observable protection against certain doses of morphine. 2. As the dose of levallorphan is increased an optimum dose is reached. If given in doses larger than this optimum dose, an additive toxic effect between levallorphan and morphine occurs. 3. In the range of additive toxicity levallorphan is approximately 7 times as toxic as morphine on a molecular basis.
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