Abstract
Summary
A variant of the Yoshida sarcoma which became resistant to Methylbis-(β-chlorethyl)-amine N-oxide (MBAO) upon passage through animals treated with the agent, has been demonstrated to be resistant to 3 other alkylating agents, Methylbis- (β-chlorethyl)-amine, Tris-(β-chlorethyl)- amine and Tris-ethylenimino-s-triazine. It proved sensitive to another unrelated antitumor agent, colchicine. Resistance to MBAO has remained unchanged following 24 consecutive serial transfers in rats free of the agent.
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