Difference in Susceptibility to Ak Leukemic Agent Between Two Substrains of Mice of G3H Line. ∗

Abstract

Summary

1. Of 320 C3H mice (substrain Bittner), inoculated with filtered Ak leukemic extracts, 28% developed leukemia. Of 162 C3H mice (substrain National Cancer Institute) inoculated simultaneously with the same extracts, only 4% developed leukemia. 2. The incidence of parotid gland tumors, induced with the leukemic extracts in these 2 groups of C3H mice, was 10% vs. 6% respectively. 3. Newborn C3H mice of the Bittner substrain are, therefore, substantially more susceptible to leukemogenic action of the Ak leukemic agent, than those of the National Cancer Institute substrain, of the same line.