Abstract
Summary
1. Δ7-Cholestenol or its acetate injected into the blood stream of the rat disappeared rapidly, less than half remaining in blood after 2 hours. At this time 34% of the injected Δ7-cholestenol was found in the lungs, spleen, and liver; 26% remained in these organs after 24 hours. 2. A substantial portion of the Δ7-cholestenol remaining was in the ester form. Injected Δ7-cholestenol acetate disappeared without any corresponding accumulation of free sterol. 3. Administration of free Δ7-sterol resulted in transient increases in the cholesterol content of blood, liver, lungs, and spleen. No comparable increases followed the injection of Δ7-cholestenol acetate.
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