Abstract
Summary
1. Destruction or removal of erythrocytes from extravascular sites was investigated by the use of cells tagged with radioactive sodium chromate and counted in vivo. Limitations and usefulness of the method were studied. 2. Autogenous erythrocytes disappeared from subcutaneous and intramuscular tissues of rabbits in 2-3 days. Less than 3% of the tagged cells appeared in the circulation. 3. After injection of autogenous cells into peritoneal cavity of rabbits, 56-92% of the cells appeared within 1-3 days in the circulating blood and exhibited a normal lifespan. 4. Autogenous cells injected into the right pleural cavity of rabbits appeared in the blood slowly with only 21-34% maximum absorption in 4-7 days. 5. After injection of autogenous cells in the spinal canal of rabbits, the radioactivity disappeared very slowly. 6. Human cells injected into the subcutaneous and intramuscular tissues of rabbits disappeared more rapidly from immunized animals with circulating antibody than from non-immunized animals.
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