Abstract
Summary
Resistance to chloramphenicol in M. pyogenes is accompanied by 1) high endogenous respiration, 2) loss of ability to oxidize pyruvate and acetate, and 3) increased formation of lactic acid from glucose. The antibiotic exerts no depressant effect on any of these reactions carried out by a strain sensitive to the drug. Attempts to reconstitute the pyruvate oxidase system of intact cells resistant to the antibiotic have been unsuccessful.
Get full access to this article
View all access options for this article.