Abstract
Summary
A portal type of fatty liver has been rapidly and consistently produced in stock weanling rats by feeding diets in which the protein was exclusively of plant origin (corn, rice, wheat or cassava). This experimental lesion bears a similarity to the type of fatty liver seen in the human disease kwashiorkor. Within one week on a corn meal diet excess fat appeared in the portal region of the liver lobule and increased in amount over the 12-week period of study. Even with large concentrations of fat, the portal areas were clearly the most seriously involved.
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