Abstract
Summary
1. To 10 groups of 6 to 10 adult specimens of Triturus v. viridescens cortisone acetate, cortisone alcohol, or ACTH was administered for periods of 27-37 days. Four groups of control animals were injected with saline or maintained in tap water or saline. The right forelimbs of all animals were amputated midway between the elbow and carpal region one day following the beginning of treatment. 2. There was no appreciable retardation of limb regeneration in any of the groups. 3. Marked deposition of fat was observed in the lateral renal tubules of animals treated with ACTH, the concentration deposited being approximately proportional to the dose of ACTH. 4. Adrenal cortical tissue of salamanders maintained in the higher concentration of cortisone alcohol (40 mg/1) was found to have undergone a reduction in the lipid droplets which are characteristically present in the normal gland.
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