Abstract
Summary
Studies on amino- and ammonium-alkylaminobenzoquinones directed our attention to the unique property of the quaternizing agent, 2-chlorobenzyl chloride, in increasing their anticholinesterase activities. This was applied to amides of dicarboxylic acids, and N, N'-bis(2-diethylaminoethyl) ox-amide bis-2-chlorobenzyl chloride (Win 8077) was synthesized. It was observed to be about 6 times as effective as neostigmine methyl sulfate as an inhibitor of red cell cholinesterase.
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