Abstract
Summary
A method was described for the isolation of antigens from the supernates of H. capsulatum yeast phase cultures by precipitation with zinc and alcohol accompanied by removal of protein by the water-chloroform method. Antigens prepared by this method fixed complement only with sera from rabbits infected with H. capsulatum. The antigens reacted with serum from both early and late bleedings of Histoplasma-infected rabbits, but failed to react with serum from animals with B. dermatitidis, C. immitls, S. schenckii, and C. albicans.
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