Abstract
Summary
1. Hepatic ischemia was produced by closure of the hepatic artery and portal vein of dogs for periods of 1 to 2 hours. This caused, in the majority of instances, a rapid and often profound decrease in mean arterial blood pressure, with concomitant sharp increase in portal venous pressure, following restoration of blood flow through the anoxic liver. The animals were usually able to compensate with partial to complete restoration of blood pressure, and simultaneously some degree of reduction of portal pressure during 1 I/2 hours of observation following ischemia. However one animal (1 I/2 hour ischemia) entered a declining phase of arterial pressure one hour after ischemia, and a second animal (2 hour ischemia) died 75 minutes after ischemia. Possible mechanisms for the hemodynamic alterations are discussed. 2. BSP extraction was reduced in only one of 5 experiments in which ischemia was of one hour's duration. However, extraction was usually markedly reduced following 1 I/2 to 2 hours of ischemia, with zero extraction or nearly so being a common finding in individual arterio-venous comparisons.
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