Influence of Cortisone,Pironlen and ACTH on Susceptibility of Embryonated Eggs to Fowl-Pox Virus

Abstract

Summary and Conclusions

1. The pre-and post-treatment of embryonated eggs with 1.25 mg of cortisone by the chorioallantoic and allantoic cavity routes significantly decreased the susceptibility of the chorioallantois to infection with the fowl-pox virus as measured by EID₅₀ determinations and marked reduction in development of virus lesions. However, the incubation of diluted virus with cortisone (1.25 mg/ml), prior to inoculation onto the chorioallantois, did not alter the EID₅₀, nor was the development of the virus lesions impaired. 2. The pre- and post-treatment of embryonated eggs with various concentrations of Piromen or constant quantities of ACTH (1.25 mg) by the chorioallantoic and allantoic cavity routes failed to alter the susceptibility of the chorioallantois to infection with the fowl-pox virus. Likewise, the incubation of Piromen with virus at room temperature failed to alter the infectivity of the fowl-pox virus. 3. Simultaneous treatment of eggs with cortisone and Piromen or ACTH resulted in inhibition of the effects observed with cortisone alone. Moreover, the reduction in lesion size, although discernible, was not as great as with cortisone.