Abstract
Summary
Hypotension was induced in intact rats by dietary deprivation of potassium. Cortisone administration to such rats rapidly restored their blood pressures to normotensive levels. In these animals as well as in intact and uninephrectomized rats with and without a ligature about the remaining kidney and which were fed stock ration, cortisone did not appear to alter significantly their vascular responsiveness to pressor drugs. The data in this study suggest the restorative effect of cortisone upon blood pressure of potassium-depleted, hypotensive rats is not accounted for by augmentation of vascular responsiveness to pressor substances.
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