Abstract
Summary
1. It appears that conjugated corticoids (Porter-Silber chromogens) are present in human plasma which may be released by hydrolysis with beta-glucuronidase. 2. Under normal conditions the quantity of corticoids is approximately equal to the free. Under some circumstances, such as in Cushing's syndrome, the conjugates may exceed the free fraction. 3. Stress, ACTH or the administration of compounds E or F lead to elevations in the conjugated as well as the free fractions. The rate of disappearance of the free fraction is in part related to conjugation. 4. The rate of conjugation of corticoids in human plasma has been found to be defective in subjects with disease of the liver.
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