Effect of SKF Compound 525A on Excretion of Pentothal-S 35 in Mice. ∗

Abstract

Summary

Administration of SKF Compound 525A to mice (50 mg/kg, 75 mg/kg) prolongs significantly Pentothal-induced sleeping time, the duration of which is dependent on the dose of SKF-525A. The excretion of tracer amounts of Pentothal-S³⁵ has been shown to be delayed by pretreatment with SKF-525A. Over a 7 hour period control animals excreted the maximum percentage of the injected dose (13.455%) within one hour, while treated animals retained S³⁵ until the fourth hour after injection (11.228%). At the end of the 7 hour observation period, 31.1 and 30.08% of the injected doses were recovered from treated and control series, respectively. These observations are being extended to other barbiturates and the possible mechanism of action of SKF-525A.