Effect of Adrenocortical Hormones on Presence of C-reactive Protein in Blood. ∗

Abstract

Summary and conclusions

The C-reactive protein response in human blood following intravenous injections of typhoid vaccine is described. No significant alteration in the promptness, intensity or duration of this response was noted during the administration of cortisone, ACTH or salicylates. 2. In rabbits the response of the analogous Cx-reactive protein to experimental pneumococcal inf ection is similarly not modified by the adrenal cortical hormones. 3. The experimental results support the clinical impression that the disappearance of C-reactive protein from human blood during antirheumatic therapy with adrenalcortical hormones or with salicylates is secondary to suppression of the inflammatory process rather than a primary effect of these agents upon the metabolism of the C-reactive protein.