Abstract
Summary
A standardized laparotomy wound was produced in mice following a whole body x-ray dose of 500 r. The tensile strength of the healing wounds was compared on several post-operative days to wounds in unirradiated mice. In addition, 30 day mortality was determined for mice subjected to wounding, to irradiation, and to wounding plus irradiation. Irradiated animals showed a significant retardation of wound healing from the 6th through the 11th day after wounding, but not thereafter. Wounding did not alter post-irradiation mortality.
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