Inhibition of Degradation of Insulin-I 131 in vivo. ∗

Abstract

Summary

Insulin-I¹³¹ degradation in rats in vivo was not inhibited by the administration of zinc in the diet, or by treatment with the substance, polyphloretin phosphate. Marked inhibition was obtained by the intravenous or prolonged oral administration of 5-isopropylidene-2,4-dithiohydantoin and it was suggested that this may explain the protection afforded against diabetes by this substance in the partially depancreatized rat.