Abstract
Summary
1. Rickets was produced in rats thyroparathyroidectomized at 21 to 23 days of age as readily as in control animals. Both groups were on a rachitogenic diet with a calcium to phosphorus ratio of 10.3. X-ray routine histologic examination, and blood chemical analysis for calcium and phosphate were comparable in both groups of rachitic animals. 2. Rachitic bone cartilage from thyroparathyroidectomized rats calcified to the same degree as the rachitic bone cartilage from the controls. 3. Under the conditions of this experiment, neither the secretions from the parathyroid glands nor any enzyme system such as that involving bone citrogenase is essential for satisfactory in vitro calcification.
Get full access to this article
View all access options for this article.