Abstract
Summary
1. Injection of sodium aceto-acetate, in low concentrations up to 200 mg/kg) stimulated biosynthesis of ascorbic acid in rats and did not disturb carbohydrate metabolism by raising blood sugar level. 2. This compound at higher concentration (600 mg/kg), however, depressed such biosynthesis, raised blood sugar and depleted liver and muscle glycogen in rats. 3. Sodium β-hy-droxybutyrate depressed biosynthesis of ascorbic acid in rats. 4. Rabbits failed to synthesize ascorbic acid after acetoacetate or β-hy-droxybutyrate injection. 5. Depression in biosynthesis of ascorbic acid in animals is shown to be associated with disturbance in carbohydrate metabolism.
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