Abstract
Summary
1. The ATPase activity of rat brain homogenates prepared in 0.25 M sucrose was not affected by 1 × 10-4 M 2,4-dinitrophenol, 1 × 10-4 M chlortetracycline, 1.55 × 10-3 M chloramphenicol, or 1 × lQ-3 M levels of various barbiturates, in contrast to the effects of these compounds on liver homogenates prepared in the same way. 2. If EDTA was added either before or after homo-genization, so that the final concentration in the reaction mixture was 1 × 10-4 M, the ATPase activity of the brain homogenates was considerably reduced and susceptible to stimulation by the above compounds.
Get full access to this article
View all access options for this article.