Nitrogen Mustard as a Teratogenic Agent in the Mouse. ∗

Abstract

Summary

A single intra-abdominal injection of nitrogen mustard in an amount equivalent to about 1 μg per g of body weight and administered on the 10th to 12th day of gestation has no apparent effect on a pregnant mouse, but may have a pronounced effect on the young in utero. Some of the latter are killed outright and others show a wide range of resultant anomalies. Only anomalies involving the feet are reported here. The grades and distribution of deficiencies in the feet reveal a significant difference in responses on the 2 sides of the body and a considerable developmental autonomy on the part of each individual foot.