Pantothenic Acid Deficiency Induced in Human Subjects. ∗

Abstract

Summary

1. An abnormal metabolic state has been induced in 4 human volunteers through combined use of a diet deficient in pantothenic acid and a metabolic antagonist, (omega-methyl pantothenic acid). 2. This abnormal state was accompanied by clinical and biochemical abnormalities suggesting adrenal cortical insufficiency, and by a peripheral neuropathy. 3. Administration of pantothenic acid alone did not immediately reverse the abnormal state. A good diet of natural foods and multiple vitamins resulted in rapid complete recovery.