Abstract
Discussion and Summary
The present results are in conformity with the data of Galloway and Elford5 concerning the instability of vesicular stomatitis virus at pH values of 4.0 or less. The use of more sensitive experimental hosts and determination of 50% mortality endpoints, however, showed that in-activation of virus was achieved only at pH 2.0. Extension of studies beyond the pH value of 9.6 reported by Galloway and Elford (5) revealed the striking resistance of virus to inactivation by alkaline environments. It would appear that the wide range of stability of vesicular stomatitis virus may render it a likely prospect for purification by means of the ion exchange resins.
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