Abstract
Summary
The responses of the lipid fractions of the liver; and liver and plasma electrolytes to alloxan administration were determined at 4, 24, and 12 hours. The adrenal ascorbic and cholesterol concentrations were also measured as indices of adrenocortical activation in these animals. Besides the known responses of hyperglycemia and decreased liver glycogen content, there were similar changes in other chemical constituents in all groups—an increased neutral fat and decreased liver potassium content, and an increased plasma potassium level. The changes in the tissue chemistries of the 4- and 24-hour groups after alloxan were discussed as signs of an hepatotoxic action of alloxan, or responses of a stress type which were adreno-cortically conditioned. It was also shown that the nature of the altered chemistries 72 hours after alloxan were essentially the same in intact and adrenal-demedullated rats.
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