Abstract
Summary
Purified pancreatic hyperglycemic factor has been given to normal rats during a period of fasting or at the end of such a period. In the latter case HGF caused a fall in the level of ketonemia which had developed as a result of the fast, but did not affect the blood sugar. When given during the fast, HGF greatly inhibited the development of ketonemia, increased the nitrogen excretion, and inhibited to some degree the rise in liver fat; it did not affect the liver glycogen or the blood sugar. These effects differ from those of adrenal hormones and of growth hormone. It appears that HGF is capable of playing an active part in fasting metabolism.
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