Abstract
Summary
A micro-method utilizing blood from tail vessels has been devised for determining the BSP-retention of mice. This method has been shown to be a reliable test for altered function of livers damaged by CC14. When applied to mice at varied intervals after PVP administration, the BSP-retention values were invariably within the normal range. Increasing the dosage and the molecular size of the PVP did not increase the dye-retention. The results indicate that PVP, as used in this investigation, does not alter the mechanism of BSP-removal from the blood of normal animals, and it does not cause impaired liver function, either immediate or deferred, as determined by the BSP-retention test.
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