Contribution to the Pharmacology of Apoatropine and Its Methyl Bromide

Abstract

Summary and Conclusions

1. Apoatropine is about 20 times more acutely toxic than atropine. 2. On the isolated rat's intestine atropine and apoatropine elicit about the same degree of antispasmodic action. 3. In the intact rat, apoatropine is approximately one-fortieth as active as atropine in producing the tranquilization of the small intestine. 4. Apoatropine is a potent cardiac depressant in the dog. 5. By quaternizing apoatropine one enhances markedly its toxicity without appreciable effect upon its antispasmodic action.