Abstract
Summary and Conclusions
1. In these experiments, ulcer pain was produced in 4 of 7 duodenal ulcer patients by the intraduodenal administration of N/10 HCl at a rate which lowered duodenal pH to 1.88 or less. 2. Onset of ulcer pain was not associated with any change in duodenal motility. 3. Ulcer pain induced by intraduodenal HCl was not relieved by anticholinergic drugs, even though duodenal motility was abolished. 4. When duodenal pH was elevated by neutralization or aspiration, ulcer pain was relieved. 5. Intraduodenal HCl constantly inhibited motility of the gastric antrum.
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