Abstract
Summary
The previously established specific action of salicylic acid on the adrenal-pituitary system has been investigated as to duration, effect of repeated doses of salicylic arid, effect of pre treatment with cortisone and possible mechanism of action. The effect of a single injection of salicylic acid (300 mg/kg) lasted more than 16 hours, at which time still appreciable bloodlevels of salicylic acid were present. Repeated injections of salicylic acid did not impair the responsiveness of the adrenals. Pretreatment with cortisone reduced, but did not abolish the effect of salicylic acid. Complete anesthesia with pentobarbital blocked the effect of salicylic acid. The results are interpreted as an effect of salicylic acid on the hypothalamus with subsequent stimulation of the pituitary.
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