Abstract
Summary
1. Intraperitoneal injections of carbon tetrachloride in rats fed a dl-tryptophane supplemented nicotinic acid-deficient diet lowered urinary excretion of nicotinic acid, quinolinic acid and N-MN. 2. Liver homogenates of normal rats converted tryptophane to quinolinic acid more efficiently than that of carbon tetrachloride-treated rats. 3. It is suggested that liver is the principal site of synthesis of nicotinic acid and quinolinic acid from tryptophane.
Get full access to this article
View all access options for this article.