Steroids in Adrenal Venous Blood of the Dog

Abstract

Summary

Concentrations of steroids in arterial and venous blood of the adrenal have been determined. Those steroids whose concentrations in the blood are increased by passage through the gland are considered to be adrenal secretory products. Three steroids are consistently of adrenal origin: 17-hydrox-ycorticosterone, Fraction 8, and corticoster-one. In 2 of 3 experiments 11-desoxy-17-hy-droxycorticosterone was contributed to the blood by the adrenal gland. A steroid less polar than corticosterone (Fraction 13) also appeared to be an adrenal secretory product in 2 of 3 experiments. Five substances (Fractions 2, 5, 77 9, and 10) are clearly not secreted by the adrenal gland, since they were found in the same concentrations in arterial blood as in adrenal venous blood. The status of 4 substances (Fractions 1, 3, 4, and 14) as adrenal secretory products has not been established. 17-Hydroxycorticosterone and corticosterone, when added to arterial blood, are recovered without substantial alteration in the pattern of steroids present in such blood.